Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. He has decided to stay on the same dose rather than increase it to see if it stabilises. and the drug was replaced after a … xx Possible Side Effects. You will need frequent blood and urine checks. The contraindications are textbook I understand , although I am not a GP or specialist. I hope it settles down for you and works well for your RA. The most common side effects are nausea or abdominal discomfort. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. I had this problem about twenty years ago. All drugs may cause side effects. Some side effects that are sulfasalazine might not require any medical attention. Dental work should be delayed until your blood counts have returned to normal. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. However, many people have no side effects or only have minor side effects. The most common side effects include: Upset stomach; Diarrhea; Nausea/vomiting; Headache; Appetite loss; Skin sensitivity; Approximately 10% of patients taking Sulfasalazine experience a skin rash. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. But I think it must be - after all, side effects are only known by getting feedback from the people using the drug. Sulfasalazine may cause side effects. Stomach pain or heartburn. Certainly it went away when i stopped taking it. Sulfasalazine causes temporary infertility in males. Sulfasalazine Side Effects. He's tried a couple of other tablets but had to stop those due to side effects such as blisters etc. Give as directed by your veterinarian. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Visit your doctor or health care professional for regular checks on your progress. The Sulphasalazine is a DMARD and this can effect the white blood cells, sometimes they will withdraw the Dmard and try another one. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Try not to let more than 8 … When taking Sulfasalazine, reported side effects are usually mild and improve in time. These negative effects might evaporate as the body gets used to the medication. My husband started on sulfasalazine a week ago on two a day. Keep out of the sun. In rheumatoid arthritis, the effect of sulfasalazine delayed release tablets can be assessed by the degree of improvement in the number and extent of actively inflamed joints. It is best to take this medicine right after meals, at evenly spaced times throughout the day and night. Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. 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